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Effects of the steroidal antiandrogen win 49596 on fertility and sex accessory tissue growth in the rat
Author(s) -
Batzold Frederick H.,
Winneker Richard C.,
Snyder Ben W.,
Reel Jerry R.
Publication year - 1990
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430210104
Subject(s) - endocrinology , antiandrogen , medicine , androgen , seminal vesicle , antagonist , prostate , biology , androgen receptor , spermatogenesis , flutamide , testosterone (patch) , andrology , prostate cancer , hormone , receptor , cancer
Daily administration (20–500 mg/kg) of the steroidal androgen receptor antagonist, Win 49596, to mature male rats for 72 days caused a significant dose‐related inhibition of sex accessory tissue growth that also correlated with Win 49596 blood levels. Cohabitation of treated males with cycling females for up to 7 days after 29 and 65 days of treatment resulted in no significant effects on insemination or pregnancy rates as compared to vehicle‐treated controls. Furthermore, testicular growth was normal and there was no histomorphological evidence for effects on spermatogenesis. The data suggested that the androgen antagonist, Win 49596, selectively inhibited prostatic and seminal vesicle growth without compromising reproductive function. This tissue selectivity is explicable on the basis of the high levels of androgen in testicular fluid as compared to prostatic tissue.