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Effects of RO 15‐4513 and FG 7142 alone and in combination with ethanol on avoidance in the rat
Author(s) -
Galizio Mark,
Biddison Elizabeth S.
Publication year - 1990
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430200109
Subject(s) - timeout , antagonist , chemistry , ethanol , pharmacology , avoidance response , alcohol , psychology , neuroscience , medicine , biochemistry , receptor , mathematics , statistics
Rats were trained on a complex avoidance schedule in which responses on one lever postponed shock and responses on another lever occasionally (variable‐interval 45 sec schedule) produced 2 min periods of timeout from avoidance. As shown in previous experiments, ethanol (1.5 or 2.0 g/kg) produced an increase in timeout responding relative to avoidance lever rates. These effects were attenuated in five of the six rats by 6 mg/kg RO 15‐4513, a dose that did not produce consistent intrinsic effects. In contrast, FG 7142 (10 mg/kg) reliably reversed ethanol effects in only one of the six rats tested. These results support the notion that RO 15‐4513 possesses specific ethanol antagonist properties.