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Effects of chronic imipramine and haloperidol treatment on apomorphine‐induced motility in rats
Author(s) -
Pradhan Nityananda,
Moro Sulochana D.,
Srinivasan Aruna S.
Publication year - 1989
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430180203
Subject(s) - apomorphine , haloperidol , imipramine , dopamine receptor , pharmacology , motility , endocrinology , postsynaptic potential , dopamine , dopamine agonist , medicine , chemistry , receptor , dopaminergic , biology , alternative medicine , pathology , genetics
Abstract Locomotor behavior was studied with the use of automated devices in chronic imipramine‐ and haloperidol‐treated Sprague Dawley rats. The biphasic response to apomorphine was only preserved in the control rats. The response to low dose apomorphine challenge was attenuated by chronic imipramine and haloperidol administration. There were no significant changes in motility responses to high dose apomorphine challenges between the control and experimental groups. The results suggest the involvement of postsynaptic Dopamine receptors (D2) in the loss of response to low dose apomorphine.