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Discriminative stimulus properties of the non‐sedative anxiolytic benzodiazepine receptor ligand RU 32698
Author(s) -
Gardner Colin R.
Publication year - 1989
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430180103
Subject(s) - chlordiazepoxide , inverse agonist , benzodiazepine , zolpidem , chemistry , anxiolytic , pharmacology , agonist , flumazenil , gabaa receptor , partial agonist , sedative , receptor , psychology , diazepam , medicine , biochemistry , insomnia
Gardner, C.R.: Discriminative stimulus properties of the non‐sedative anxiolytic benzodi‐ azepine receptor ligand RU 32698. Drug Dev. Res. 18:ll–18, 1989. Rats were trained to discriminate RU 32698 (10 mg/kg p.o.) from vehicle using a fixed‐ratio 20 drug discrimination procedure. The characteristics of this cue were compared with that evoked by training rats to discriminate a low dose of chlordiazepoxide (CDZP, 5 mg/kg p.o.) from vehicle. Both cues were antagonized by the benzodiazepine inverse agonist FG 7142, and by the weak inverse agonist CGS 8216. Each training drug substituted for the cue induced by the other. Several benzodiazepine receptor ligands substituted for both cues at similar doses (zopiclone, zolpidem, ZK 91296, RU 43028), although there was a tendency for only partial generalization with ligands with only weak agonist activity (RU 39419, CGS 9896, RU 32514). CL 218872 partially substituted for the RU 32698 cue. Tracazolate partially substituted for both cues but buspirone showed little or no substitution for either cue. Thus, RU 32698 induces a cue via an action at benzodiazepine receptors. The RU 32698 cue is sensitive to low levels of agonism at benzodiazepine receptors and should be useful in the discovery of non‐sedative anxiolytic agents.