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New n‐methyl‐d‐aspartate antagonists for the treatment of stroke
Author(s) -
PorscheWiebking Elena
Publication year - 1989
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430170410
Subject(s) - nmda receptor , neurotoxicity , glutamate receptor , stroke (engine) , pharmacology , neuroscience , neurotransmitter , excitatory postsynaptic potential , ischemia , medicine , receptor , chemistry , anesthesia , biology , toxicity , mechanical engineering , engineering
Current research indicates that the neurotoxicity of the excitatory amino acid neurotransmitter glutamate contributes to the cell loss associated with a variety of neurological disease states. In particular, glutamate neurotoxicity has been proposed to play a key role in ischemic/hypoxic neuronal cell death and the development of ischemic brain damage. Certain N‐methyl‐ D ‐aspartate (NMDA) receptor/channel complex antagonists have been shown to protect against experimentally induced hypoxic/ischemic injury. Concepts for the development of novel NMDA antagonists for the treatment of stroke are discussed.