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Modification of ischemia‐induced biochemical changes in the myocardium by Rooh‐Afza extracts
Author(s) -
Dikshit Madhu,
Srivastava Ranjana,
Srimal Rikhab Chand,
Dhawan Bhola Nath
Publication year - 1989
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430170308
Subject(s) - isoprenaline , ischemia , ex vivo , in vivo , chemistry , in vitro , adenosine diphosphate , pharmacology , adenosine , platelet aggregation , platelet , medicine , biochemistry , biology , microbiology and biotechnology , stimulation
In rats, myocardial ischemia was produced by isoprenaline (80 mg/kg i.p.) and in rabbits, by ligating the anterior descending branch of the coronary artery. Two extracts of Rooh‐Afza, a Unani polypharmaceutical preparation, were administered 1 hr or 15 min before inducing ischemia. Both the extracts protected the rat myocardium from isoprenaline‐induced changes. In rabbits, protection against ischemia was observed only at a higher dose. The extract containing essential oils and flavoring agents was found to be more effective. It also inhibited platelet aggregation induced by adenosine diphosphate (ADP) in vitro and ex vivo in monkeys.