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Alpha 2 agonists and GABAergic agents reverse isoniazid‐induced convulsions in mice
Author(s) -
Aley K. O.,
Kulkarni S. K.
Publication year - 1989
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430170210
Subject(s) - gabaergic , diazepam , pharmacology , agonist , idazoxan , anticonvulsant , baclofen , chemistry , alpha (finance) , clonidine , yohimbine , medicine , epilepsy , endocrinology , antagonist , inhibitory postsynaptic potential , receptor , biochemistry , construct validity , nursing , psychiatry , prazosin , patient satisfaction
The effects of GABAergic agents (GABA, fengabine, baclofen) and alpha 2 agonists (clonidine and BHT‐920) on isoniazid (INH)‐induced convulsions in mice were studied. All the GABAergic agents and alpha 2 agonists employed in the study provided significant protection against INH‐Induced convulsions and death. The protective effects of alpha 2 agonists were sensitive to blockade by yohimbine or idazoxan. When a subeffective dose of alpha 2 agonist or GABAergic agent was concomitantly administered with a subeffective dose of diazepam, a potentiation of the anticonvulsant effect of diazepam was observed. Alpha 2 agonists through GABAergic mechanism offer protection against INH‐induced seizures in mice.