Alpha 2  agonists and GABAergic agents reverse isoniazid‐induced convulsions in mice | Zendy

Aley K. O. | Zendy; Kulkarni S. K. | Zendy

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Alpha 2 agonists and GABAergic agents reverse isoniazid‐induced convulsions in mice

Author(s) -

Aley K. O.,

Kulkarni S. K.

Publication year - 1989

Publication title -

drug development research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.582

H-Index - 60

eISSN - 1098-2299

pISSN - 0272-4391

DOI - 10.1002/ddr.430170210

Subject(s) - gabaergic , diazepam , pharmacology , agonist , idazoxan , anticonvulsant , baclofen , chemistry , alpha (finance) , clonidine , yohimbine , medicine , epilepsy , endocrinology , antagonist , inhibitory postsynaptic potential , receptor , biochemistry , construct validity , nursing , psychiatry , prazosin , patient satisfaction

The effects of GABAergic agents (GABA, fengabine, baclofen) and alpha 2 agonists (clonidine and BHT‐920) on isoniazid (INH)‐induced convulsions in mice were studied. All the GABAergic agents and alpha 2 agonists employed in the study provided significant protection against INH‐Induced convulsions and death. The protective effects of alpha 2 agonists were sensitive to blockade by yohimbine or idazoxan. When a subeffective dose of alpha 2 agonist or GABAergic agent was concomitantly administered with a subeffective dose of diazepam, a potentiation of the anticonvulsant effect of diazepam was observed. Alpha 2 agonists through GABAergic mechanism offer protection against INH‐induced seizures in mice.

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