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Propranolol induces hyperreactivity in lung parenchyma strips from sensitized guinea pigs
Author(s) -
Vargas Mario H.,
Montaño Luis M.,
Vanda Beatriz,
Selman Moisés
Publication year - 1989
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430170205
Subject(s) - propranolol , ovalbumin , parenchyma , guinea pig , contraction (grammar) , lung , histamine , blockade , bronchoconstriction , chemistry , immunology , in vivo , airway resistance , medicine , pharmacology , endocrinology , antigen , biology , pathology , asthma , receptor , microbiology and biotechnology
Propranolol causes airway hyperreactivity to agonists or antigenic challenge in vivo, but its mechanisms are still debated. In this study we found that the addition of propranolol (10 μ/ml) to lung parenchyma strips from sensitized guinea pigs enhanced the sensitivity and maximum contraction to antigenic challenge (ovalbumin, 0.01–100 μ/ml) and the sensitivity to histamine (1 × 10 −7 to 1.7 × 10 −4 M), determined through concentration‐response curves. In contrast, tracheal chains from sensitized guinea pigs were unaffected. These results in in vitro preparations strongly suggest that, at least in lung parenchyma tissue, other mechanisms different from beta‐blockade are present in propranolol‐induced airway hyperreactivity.