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Effects of H 2 ‐receptor antagonists on the central nervous system
Author(s) -
Berlin Roger G.
Publication year - 1989
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430170202
Subject(s) - central nervous system , receptor , neurotransmitter , neuroscience , biology , neurotransmitter receptor , blood–brain barrier , pharmacology , chemistry , biochemistry
Histamine functions as a neurotransmitter in the central nervous system (CNS), and H 2 ‐receptor activation can modulate the activity of the CNS. H 2 ‐receptor antagonists are known to penetrate the blood‐brain barrier and to cause neuropsychiatric effects. It appears that interactions with CNS H 2 ‐receptors may account for many of these effects, although receptor interactions unique to certain H 2 ‐antagonists may also play a role.
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