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Generalization of cocaine to the isomers of 3,4‐Methylenedioxyamphetamine and 3,4‐methylenedioxyamethamphetamine: Effects of training dose
Author(s) -
Broadbent Julie,
Michael Elizabeth K.,
Appel James B.
Publication year - 1989
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430160238
Subject(s) - mdma , amphetamine , stimulant , stimulus generalization , pharmacology , psychology , dextroamphetamine , saline , generalization , drugs of abuse , enantiomer , stimulus control , drug , anesthesia , chemistry , medicine , neuroscience , dopamine , stereochemistry , nicotine , mathematical analysis , mathematics , perception
MDA and MDMA are popular recreational drugs which have considerable abuse potential and may be neurotoxic. Because these compounds have sometimes been reported to have behavioral effects that resemble those of d ‐amphetamine, the stimulus properties of all of the enantiomers of both MDA and MDMA were analyzed in animals trained to discriminate another abused stimulant, cocaine, from saline. Since the extent of generalization of any drug depends on training dose, separate groups of rats were trained to detect 3.5, 10.0, or 20.0 mg/kg of this compound. The results indicate that all of these doses of cocaine maintain discrimination behavior reliably and consistently and that the three cues are qualitatively similar. Among all the individual enantiomers of MDA and MDMA, only d ‐MDA mimicked cocaine; however, this effect occurred consistently only in the group trained to detect the lowest dose (3.5 mg/kg).