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Discriminative stimulus‐ and schedule‐induced rate effects of ethanol in combination with the proposed ethanol antidote Ro 15‐4513
Author(s) -
Hiltunen Arto J.,
Järbe Torbjörn U. C.
Publication year - 1989
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430160217
Subject(s) - chemistry , pentylenetetrazol , diazepam , stimulus control , ethanol , saline , pharmacology , stimulus generalization , anesthesia , medicine , biochemistry , anticonvulsant , psychology , epilepsy , nicotine , neuroscience , psychiatry , perception
Two different groups of rats were trained to discriminate, 15 min after the injections, between i.p. administered (1) ethanol (ETOH, 1.2 g/kg) or (2) pentylenetetrazol (PTZ, 15 mg/kg) from a non‐drug condition according to a drug discrimination learning (DDL) procedure. Thereafter, combinations of ETOH and Ro 15‐4513 were evaluated in both groups, as well as in a third group, which was trained according to an FR‐10 bar‐pressing procedure. Results indicated that rats trained to discriminate ETOH from saline generalized combinations of ETOH (0.9 and 1.2 g/kg) and Ro 15‐4513 (3 and 10 mg/kg) to the ETOH stimulus. Rats trained to discriminate PTZ from saline (1) disclosed generalization to the PTZ stimulus with Ro 15‐4513 (10 mg/kg) but not with ETOH 0.3–1 g/kg, (2) generalized the effects of combinations of Ro 15‐4513 (10 mg/kg) and ETOH (0.3–1 g/kg) to the PTZ stimulus, and (3) diazepam (DZP, 3 mg/kg) and Ro 15‐1788 (10 mg/kg) antagonized the PTZ‐like discriminative stimulus effects of Ro 15‐4513 (10 mg/kg). Rats trained to press a bar disclosed increases in the response time after treatments with ETOH (0.9 and 1.2 g/kg) and Ro 15‐4513 (3 and 10 mg/kg) as did the DDL animals. Thus, (1) Ro 15‐4513 did not seem to reverse any of the recorded behaviors induced by ETOH, and (2) both DZP and Ro 15‐1788, however, reversed the generalization of Ro 15‐4513 to the PTZ stimulus.