Comparison of the effects of clonidine, rilmenidine, and guanfacine in the holeboard and elevated plus‐maze | Zendy

Johnston Amanda L. | Zendy; KoeningBerard Elisabeth | Zendy; Cooper Teresa A. | Zendy; File Sandra E. | Zendy

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Comparison of the effects of clonidine, rilmenidine, and guanfacine in the holeboard and elevated plus‐maze

Author(s) -

Johnston Amanda L.,

KoeningBerard Elisabeth,

Cooper Teresa A.,

File Sandra E.

Publication year - 1988

Publication title -

drug development research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.582

H-Index - 60

eISSN - 1098-2299

pISSN - 0272-4391

DOI - 10.1002/ddr.430150407

Subject(s) - guanfacine , clonidine , rilmenidine , chemistry , agonist , imidazoline receptor , ed50 , endocrinology , medicine , pharmacology , receptor , biochemistry

The effects of clonidine, rilmenidine, and guanfacine were studied in the holeboard and elevated‐plus maze tests in rats. In the holeboard test, clonidine had a profound effect on locomotor activity, significantly ( P < 0.05) reducing this measure at all but one of the doses tested (0.005–0.25 mg/kg). In contrast, rilmenidine and guanfacine only markedly affected locomotor activity at 2.5 mg/kg or higher. The ED50

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