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Neocortical anomalies in autoimmune mice: A model for the developmental neuropathology seen in the dyslexic brain
Author(s) -
Sherman Gordon F.,
Rosen Glenn D.,
Galaburda Albert M.
Publication year - 1988
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430150219
Subject(s) - neocortex , neuropathology , neuroscience , cerebral cortex , cortex (anatomy) , biology , pathology , dyslexia , psychology , medicine , disease , reading (process) , political science , law
Developmental ectopias (nests of neurons) in the molecular layer of the cerebral neocortex and associated dysplasias of underlying layers have been seen in two strains of mice (New Zealand Black and BXSB) that spontaneously develop autoimmune disorders. The ectopias are usually unilateral and males are more often affected than females. The emerging situation is comparable to that of male dyslexics who in addition to their language problems show similar developmental brain anomalies. These anomalies are through to have their origin during the last stages of neuronal migration. We believe that maternal autoantibodies passing through the placenta and blood‐brain barrier may damage the important structural components of the cerebral cortex affecting the final positions of migrating neurons. The autoimmune mice are a useful experimental animal model for understanding the development of neuropathology in dyslexics.