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Autoantibodies, immune complexes, and behavioral disorders: Neuropsychiatric involvement in systemic lupus erythematosus
Author(s) -
Hoffman Steven A.,
Narendran Anthony,
Shucard David W.,
Harbeck Ronald J.
Publication year - 1988
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430150215
Subject(s) - autoantibody , immune system , immunology , central nervous system , affect (linguistics) , neuroscience , blood–brain barrier , disease , medicine , autoimmunity , psychology , antibody , pathology , communication
There is a great deal of interest in immune mediation of neurobehavioral disorders. In this paper we emphasize the role that immune complexes and autoantibodies are likely to play in interfering with normal central nervous system functioning. The evidence indicates that immune complexes can affect behavior, probably via C3a and C5a, and alter blood–brain barrier permeability. The evidence also indicates that brain‐reactive autoantibodies are likely to affect behavior. There is, however, a diversity of these autoantibodies which will have to be better characterized in order to truly understand their role in autoimmunemediated central nervous system disease.