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Antibodies recognizing cholinergic neurons and thyroglobuline are found in the cerebrospinal fluid of a subgroup of patients with Alzheimer's disease
Author(s) -
McRaeDegueurce Amanda,
Haglid Kenneth,
Rosengren Lars,
Wallin Anders,
Blennow Kaj,
Gottfries C.G.,
Dahlström Annica
Publication year - 1988
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430150208
Subject(s) - cholinergic , cholinergic neuron , medicine , cerebrospinal fluid , pathology , disease , antibody , neuroscience , endocrinology , immunology , biology
The presence of cholinergic neuron specific lgG in the CSF of a subgroup of patients with Alzheimerapos;s disease (AD) was demonstrated by immunocytochemistry. The lgG labeled cholinergic nerve cell bodies in the medial septum of rat brains, perfusion fixed with glutaraldehyde/allyl alcohol to fix small transmitter molecules. Many of the patient CSFs also recognized thyroglobuline in an ELISA assay. Antithyroglobuline furthermore recognized the same cholinergic neurons in the rat brain as the CSF and antiacetylcholine, as did anti‐T3 and anti‐T4. The results indicated that in a subgroup of AD patients autoimmune mechanisms may play a role in the pathogenesis of dementia, and that disturbances in the handling of thyroid hormone in the CNS may be involved in the disease process.