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Dextronatrin: A potent atrial natriuretic peptide analog; Vascular and natriuretic effects
Author(s) -
Deghenghi R.,
Immer H. U.,
Beaulieu G.,
Muirhead C. R.
Publication year - 1988
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430150109
Subject(s) - natriuresis , medicine , diuresis , endocrinology , atrial natriuretic peptide , diuretic , chemistry , npr2 , npr1 , amino acid residue , peptide hormone , excretion , natriuretic peptide , kidney , receptor , biochemistry , peptide sequence , heart failure , gene
A shortened 23 amino acid analog (dextronatrin) of rat ANP(1–28) in which, in position 6 next to Cys, there is a D‐Tyr residue, has been compared to rat ANP(1–28) for its diuretic and electrolyte‐excreting properties in male normotensive rats. Both compounds elicited an equally large but short‐lasting diuresis. The natriuresis was also short‐lasting as were the changes in Cl − and K + excretion. In a rabbit aortic strip preparation dextronatrin antagonized the vasoconstricting effects of noradrenaline but to a lesser extent than rat ANP(1–28).