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Effect of ethanol on motor activity of the colon in the rat
Author(s) -
Meshkinpour Hooshang,
Yu Jen,
Harmon David
Publication year - 1988
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430150106
Subject(s) - neostigmine , ethanol , stomach , chemistry , motor activity , saline , anesthesia , medicine , biochemistry
Abstract The present study was designed to evaluate the influence of oral and intravenous ethanol on both resting and neostigmine‐induced motor activity of the colon in the rat. Recording assemblies were implanted in the proximal and distal colon in a chronic preparation. On separate days, 2 ml of normal saline or the same volume of 10% or 25% ethanol was introduced intravenously or into the stomach. Colon motor activity was recorded at resting and after intravenous injection of 0.07 mg/kg neostigmine. Ethanol decreased the number and amplitude of the contractions. This effect occurred within a few minutes after administration of ethanol and lasted for the entire recording period of 30 min. Both concentrations of ethanol significantly ( P < 0.05) decreased the motility index of the colon. Injection of neostigmine was signified by a substantial rise in colon motor activity which was significantly inhibited by administration of ethanol. These studies indicate that ethanol, within the human legal intoxication range, inhibits the resting and neostimine‐induced motor activity in the rat colon.