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Effect of vinpocetine on the sleep‐wake cycle of rats
Author(s) -
Sarkadi Adam,
Laszy Judit,
Szporny Lászlö
Publication year - 1988
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430140326
Subject(s) - vinpocetine , alertness , hypoxia (environmental) , anesthesia , discontinuation , pharmacology , medicine , chemistry , oxygen , organic chemistry
Vinpocetine given orally for five consecutive days in weekly, ascending doses produced changes in the sleep‐wake cycle of the rat, as measured by the electrocorticogram. The effect of vinpocetine on the sleep‐wake cycle was interpreted as an increase in alertness, and was most prevalent at the highest dose of 30 mg/kg/day p.o. This effect lasted for two weeks following the discontinuation of the treatment. Hypoxia‐induced sleep disturbances were not improved by daily administration of vinpocetine in rats. These data support three conclusions: (1) vinpocetine may evoke functional and/or metabolic processes in the brain that are related enhanced alertness; (2) within the dose range examined vinpocetine had no “antihypoxic” activity during moderate hypoxic episodes; and (3) the effect of vinpocetine appears to be extended beyond the treatment period.