Effect of vinpocetine on age‐related differences in brain function of aged fischer rats | Zendy

Notvest Ronald R. | Zendy; Emrey Tracey A. | Zendy; Inserra John J. | Zendy

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Effect of vinpocetine on age‐related differences in brain function of aged fischer rats

Author(s) -

Notvest Ronald R.,

Emrey Tracey A.,

Inserra John J.

Publication year - 1988

Publication title -

drug development research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.582

H-Index - 60

eISSN - 1098-2299

pISSN - 0272-4391

DOI - 10.1002/ddr.430140325

Subject(s) - vinpocetine , anesthesia , medicine , therapeutic effect , psychology , pharmacology , neuroscience

Vinpocetine, an eburnamenine derivative, is under clinical investigation as a cerebral activator for use in Alzheimer's and other diseases characterized by symptomatic cognitive and attentional deficits. In this study, vinpocetine was evaluated by examining its effect on the electrocorticogram (ECoG) of aged (26‐month‐old) Fischer‐344 rats. Significant age‐related differences were apparent for all ECoG parameters examined, suggesting a cerebral deficit in aged rats. Vinpocetine, administered orally (p.o.) over the dose range of 0.3 to 30 mg/kg/day p.o. for 5 days, diminished the age‐related differences in the ECoG. These findings provide evidence that vinpocetine may serve as a useful therapeutic agent in diseases characterized by cerebral deficits.

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