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Multicenter clinical placebo‐controlled study with acetyl‐l‐carnitine (LAC) in the treatment of mildly demented elderly patients
Author(s) -
Cucinotta Domenico,
Passeri Mario,
Ventura Sandro,
Lannuccelli Maurizio,
Senin Umberto,
Bonati Piero Angelo,
Parnetti Lucilla
Publication year - 1988
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430140310
Subject(s) - placebo , medicine , clinical trial , rating scale , homogeneous , drug , placebo group , psychology , psychiatry , developmental psychology , physics , alternative medicine , pathology , thermodynamics
Abstract Acetyl‐l‐carnitine (LAC) was administered for 3 months, 2 g/daily, to 30 elderly patients with mild mental deterioration. Results were compared to those of a homogeneous control group of 28 patients treated with placebo. The study was carried out according to a double‐blind, randomized methodology. A complete battery of rating scales and psychometric tests was used for for evaluating the modifications induced by either drug or placebo. The statistical evaluation of results showed a sufficient clear efficacy of the drug studied: results from patients on LAC were frequently different from those receiving placebo. Therefore, LAC must be taken into consideration as a useful drug for the global treatment of demented elderly patients.