Multicenter clinical placebo‐controlled study with acetyl‐l‐carnitine (LAC) in the treatment of mildly demented elderly patients | Zendy

Cucinotta Domenico | Zendy; Passeri Mario | Zendy; Ventura Sandro | Zendy; Lannuccelli Maurizio | Zendy; Senin Umberto | Zendy; Bonati Piero Angelo | Zendy; Parnetti Lucilla | Zendy

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Multicenter clinical placebo‐controlled study with acetyl‐l‐carnitine (LAC) in the treatment of mildly demented elderly patients

Author(s) -

Cucinotta Domenico,

Passeri Mario,

Ventura Sandro,

Lannuccelli Maurizio,

Senin Umberto,

Bonati Piero Angelo,

Parnetti Lucilla

Publication year - 1988

Publication title -

drug development research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.582

H-Index - 60

eISSN - 1098-2299

pISSN - 0272-4391

DOI - 10.1002/ddr.430140310

Subject(s) - placebo , medicine , clinical trial , rating scale , homogeneous , drug , placebo group , psychology , psychiatry , developmental psychology , physics , alternative medicine , pathology , thermodynamics

Acetyl‐l‐carnitine (LAC) was administered for 3 months, 2 g/daily, to 30 elderly patients with mild mental deterioration. Results were compared to those of a homogeneous control group of 28 patients treated with placebo. The study was carried out according to a double‐blind, randomized methodology. A complete battery of rating scales and psychometric tests was used for for evaluating the modifications induced by either drug or placebo. The statistical evaluation of results showed a sufficient clear efficacy of the drug studied: results from patients on LAC were frequently different from those receiving placebo. Therefore, LAC must be taken into consideration as a useful drug for the global treatment of demented elderly patients.

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