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Prevention of scopolamine effect on the decrease of acetylcholine content by peripherally administered cholecystokinin octapeptide in some regions of the rat brain
Author(s) -
Takashima Akira,
Itoh Shinji
Publication year - 1988
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430140106
Subject(s) - acetylcholine , cholecystokinin , scopolamine , hippocampus , chemistry , striatum , endocrinology , cholinergic , choline , medicine , dopamine , receptor
Intraperitoneal injection of scopolamine at a dose of 0.5 mg/kg produced a marked decrease after 15 min in the acetylcholine (ACh) content of the frontal and temporal cortices and the hippocampus in the rat. In the parietal and occipital cortices and the striatum, the decrease in ACh content was less extensive. When rats were treated with cholecystokinin octapeptide 15 min before the scopolamine administration, the decrease in ACh was prevented in a dose‐dependent manner. The choline content was not affected significantly by these treatments.