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Acne: Androgens and microbiology
Author(s) -
Pochi Peter E.
Publication year - 1988
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430130208
Subject(s) - acne , propionibacterium acnes , seborrhoeic dermatitis , medicine , disease , hidradenitis suppurativa , dermatology , therapeutic modalities , biology , pathology
Abstract Acne, the most prevalent disease of the skin, is a multifactorial follicular disorder in which androgens and microbiology are essential for the occurrence of the pathogenic events that characterize it. The role of the androgen is to stimulate the development and secretory activity of the sebaceous gland, which performs several important actions in the etiopathogenesis of acne. The anaerobic diphtheroid Propionibacterium acnes , a resident organism in acne‐susceptible follicles, is directly responsible for much of the inflammation in acne. This review deals with a description of these events and the therapeutic modalities that have been developed in an attempt to counteract them.