Premium
Psoriasis: In vivo models for topical drug evaluation
Author(s) -
Lowe Nicholas J.
Publication year - 1988
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430130207
Subject(s) - psoriasis , hyperplasia , dermatology , medicine , population , etiology , in vivo , pathology , biology , microbiology and biotechnology , environmental health
Psoriasis is a common skin disease characterized by scaling erythematous skin plaques, which in severe cases can cover the entire skin. It affects about 2% of the population of the USA. The etiology is unknown, but the diseased skin shows a benign epidermal hyperplasia and abnormal differentiation plus dermal inflammation. There is no reproducible naturally occurring animal model for psoriasis. As a result, a variety of simulated animal models have been produced that possess some of the characteristic features, e.g., epidermal hyperplasia. These have been used to study epidermal kinetics and biochemical abnormalities associated with epidermal hyperplasia. Some of these models have also been used to study and screen for potentially effective and antipsoriatic drugs. There will always be, however, the need to study effects of new agents in carefully conducted studies on psoriasis patients to confirm efficacy.