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Triazolo antidepressants do not inhibit monoamine oxidase
Author(s) -
Hyslop Deborah K.,
Allen Lloyd E.,
Taylor Duncan P.
Publication year - 1988
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430120108
Subject(s) - nefazodone , trazodone , monoamine oxidase , antidepressant , monoamine neurotransmitter , pharmacology , chemistry , in vivo , monoamine oxidase a , monoamine oxidase inhibitor , moclobemide , medicine , biochemistry , serotonin , biology , receptor , enzyme , fluoxetine , microbiology and biotechnology , hippocampus
The nontricyclic antidepressant trazodone and the related triazolo antidepressants nefazodone and etoperidone are monoamine uptake inhibitors. We quantified the interaction of these compounds with monoamine oxidases in vitro and in vivo. All three compounds were devoid of activity in these studies. This suggests that the clinical use of trazodone, nefazodone, or etoperidone will not be associated with deleterious dietary interactions seen with monoamine oxidase inhibitor antidepressants.