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Effect of ipratropium bromide on bronchospasm induced by inhalation of hypotonic solutions
Author(s) -
Neria José Pérez,
Montaño R. Luis Manuel,
Monge L. Gilberto,
Rubio M. Horacio,
Selman L. Moisés
Publication year - 1987
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430110206
Subject(s) - ipratropium bromide , bronchoconstriction , bronchospasm , inhalation , anesthesia , medicine , ipratropium , retching , tonicity , bronchodilator , asthma , vomiting , airway
In order to determine the role of the cholinergic system in the bronchoconstriction induced by hypotonic solutions 30 subjects were studied: 15 asthmatic patients and 15 healthy volunteers to whom distilled water was administered by inhalation through ultrasonic nebulization. All asthmatic patients showed a 20% reduction of forced expiratory volume in 1 sec in relation to the initial value. Bronchospasm was not detected in any of the healthy subjects. After 24 hr, ipratropium bromide in aerosol was administered 1 hr before distilled water nebulization, and this prevented the bronchoconstriction response in 11 of the 15 asthmatic patients. These results suggest that such bronchospasm is mediated at least in part by vagal reflex.