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Small peptides and nerve growth: Therapeutic implications
Author(s) -
Taylor J. E.,
Moreau J. P.,
DeFeudis F. V.
Publication year - 1987
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430110202
Subject(s) - hormone , melanocyte stimulating hormone , medicine , endocrinology , growth hormone , potency , nerve growth factor , peptide hormone , peripheral , regeneration (biology) , thyrotropin releasing hormone , peptide , adrenocorticotrophic hormone , chemistry , pharmacology , biology , in vitro , biochemistry , receptor , microbiology and biotechnology
Studies of the effects of small peptides (<10,000 Da), i.e., fragments of naturally occurring hormones (e.g., adrenocorticotrophic hormones [ACTH]: α‐melanocyte‐stimulating hormone [α‐MSH]), hypophysiotrophic factors (e.g., growth hormone‐releasing hormone [GHRH], thyrotropin‐releasing hormone [TRH]), other growth factors, and synthetic compounds on peripheral and CNS neuronal regeneration and behavior have been reviewed and analyzed. It seems apparent that certain hormonal fragments, growth factors, and some synthetic compounds (e.g., the ACTH/α‐MSH analogue Org 2766) can enhance peripheral, and possibly CNS, nerve regeneration. Further study of newer peptide‐analogues with increased potency, longer duration of activity, and greater selectivity of action might lead to the development of therapies for certain types of nerve injury and for neurodegenerative disorders.