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Interoceptive stimuli produced by cocaine are blocked during diazepam withdrawal
Author(s) -
Wood Douglas M.,
Ranschaert Erik R.,
Lal Harbans
Publication year - 1987
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430110106
Subject(s) - diazepam , saline , pharmacology , anesthesia , psychology , self administration , cross tolerance , medicine , morphine
Abstract Rats were trained to select one lever after an intraperitoneal (ip) injection of cocaine (10 mg/kg), and an alternate lever after saline injection under a FR10 schedule of food reinforcement. Following chronic administration of cocaine (20 mg/kg/8hr), but not diazepam (80 mg/kg/8hr) for 7 days, the dose‐effect curve for the generalization of cocaine shifted twofold to the right. Subsequently, in the rats receiving chronic diazepam, RO 15‐1788, a drug known to precipitate diazepam withdrawal, failed to substitute for cocaine: however, the discriminability of cocaine (5 mg/kg) was reduced from 83% to 13% selection of cocaine‐appropriate lever after 72 hr following the last diazepam, injection. These data suggest that chronic administration of cocaine, but not diazepam, produced tolerance to the discriminative stimulus properties of cocaine, and following chronic diazepam administration and withdrawal, the stimulus properties of cocaine are antagonized.