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5‐Lipoxygenase, leukotrienes, and regulation of inflammatory responses
Author(s) -
Parker Charles W.
Publication year - 1987
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430100408
Subject(s) - lipoxygenase , arachidonic acid , leukotriene , vascular permeability , leukotriene c4 , arachidonate 5 lipoxygenase , chemistry , eicosanoid , mast cell , enzyme , leukotriene b4 , in vivo , inflammation , immunology , biology , biochemistry , asthma , endocrinology , microbiology and biotechnology
5‐Lipoxygenses are enzymes in leukocytes and mast cells that oxidize arachidonic acid to 5‐hydroperoxyeicosatetraenoic acid, which is in turn converted to a variety of products including leukotriene B 4 and the sulfidoleukotrienes (LTC 4 , LTD 4 and LTE 4 ). These substances exert a broad range of biologic actions including effects on cell migration, enzyme secretion, smooth muscle contraction in the respiratory and gastrointestinal tracts, and vascular permeability. Considerable evidence now implicates these products in a variety of acute and chronic inflammatory responses in vivo as well as in acute allergic reactions affecting the airway and skin.