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Pharmacological studies on factors influencing the collecting phase of the cystometrogram in urethane‐anesthetized rats
Author(s) -
Maggi Carlo Alberto,
Santicioli Paolo,
Meli Alberto
Publication year - 1987
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430100304
Subject(s) - cystometry , diuresis , reflex , saline , anesthesia , medicine , urinary bladder , reserpine , urination , hyperreflexia , urology , urinary system , chemistry , kidney
Abstract The effect of various pharmacological interventions on the collecting phase of cystometrogram (CMG) has been investigated by means of a new cystometric procedure in urethane‐anesthetized rats. The method involves the transvesical infusion, through a needle inserted in the bladder dome, of warm (37°C) saline at a rat (2.8 ml/h) simulating a maximal hourly diuresis value for this species. In these conditions bladder voiding is produced through the activation of a supraspinal vesico‐vesical reflex. Either chemical (6‐hydroxydopamine, reserpine) or surgical (section of hypogastric nerves) sympathectomy produced a picture of detrusor hyperreflexia and urine dripping, mimicking cystometric finding of human disease. This new procedure may be useful for screening and development of new drugs for treatment of urinary incontinence.