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Effects of flunarizine on rat cerebral cortex
Author(s) -
Reid Kennet H.,
Marrannes Roger,
Wauquier Albert
Publication year - 1987
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430100210
Subject(s) - flunarizine , cortical spreading depression , cerebral cortex , cinnarizine , cortex (anatomy) , anesthesia , medicine , pharmacology , phenytoin , ischemia , neuroscience , calcium , epilepsy , psychology , migraine , psychiatry
Flunarizine was tested using a single dose (40 mg/kg IP) and multiple doses (30 mg/kg PO presurgery) in 200–250 g male Wistar rats, using physiological measures related to the rapid ionic shift seen in cerebral cortex following a sudden insult. The threshold for initiation of a spreading depression was increased by flunarizine treatment only in rats in which the cortex had previously been injured. The time to rapid ionic shift after cardiac arrest (global ischemia) was increased by both flunarizine and phenytoin. Other measures tested showed no difference in normal cortex under flunarizine treatment. Flunarizine appears to have little or no effect on normal cortical tissure, but rather seems to exert a therapeutic effect on injured cortical tissue. Flunarizine may be a useful agent in the management of cerebral trauma.