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Lack of interaction of MDL 257 and isoproterenol: Comparison with aminophylline
Author(s) -
Abdallah Abdulmuniem H.,
Burnell Jim,
Cerimale Ben
Publication year - 1987
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430100207
Subject(s) - aminophylline , bronchodilator , isoprenaline , chemistry , pharmacology , medicine , endocrinology , asthma , stimulation
MDL 257 [8‐methyl‐6‐piperidino‐s‐triazolo(4,3‐b)pyridazine], a potential bronchodilator, was evaluated for potential interactions with isoproterenol on isolated tracheal smooth muscle taken from either prednisone‐ or methocel HG‐treated guinea pigs. Its effects were compared to those of aminophylline. In tracheas taken from methocel HG‐injected animals, aminophylline lowered the height of isoproterenol concentrations‐effect curve more than the vehicle ( P < .001) and shifted the curve to the left ( P < .05). MDL 257, on the other hand, had no effect. In tracheas taken from prednisone‐treated animals, aminophylline and MDL 257 had no significant effect on the maximum relaxation caused by isoproterenol. However, both drugs shifted isoproterenol concentrations‐effect curve to the left. Their effects were significantly different ( P < .05) from that of the vehicle. These data suggest that, if given together, MDL 257 would not attenuate the bronchodilator effects of betasympathomimetic amines.