Premium
The effects of clovoxamine on sleep of normal volunteers: A double‐blind placebo‐controlled study
Author(s) -
Wilson William H.,
Ban Thomas,
Coleman Bernard,
Vause Beth,
Papadatos John
Publication year - 1986
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430090406
Subject(s) - placebo , sleep (system call) , psychology , double blind , latin square , electroencephalography , double blind study , anesthesia , imipramine , slow wave sleep , audiology , medicine , psychiatry , rumen , chemistry , alternative medicine , food science , pathology , computer science , fermentation , operating system
Abstract In a double‐blind placebo‐controlled study the effects of clovoxamine on sleep were evaluated. Each of 12 healthy male volunteers was given clovoxamine (50 and 150 mg) and placebo according to a repeated‐measures randomized Latin square design. All night sleep EEGs and subjective evaluations of sleep were recorded on each night. Clovoxamine was found to have effects on sleep EEG and subjective evaluation that were consistent with findings reported for other antidepressants such as imipramine.