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An efficient method to evaluate protective drugs against regional ischemia of the heart
Author(s) -
Vandeplassche Godelieve,
Wouters Luc,
Hermans Carlo,
Xhonneux Raymond,
Borgers Marcel,
Flameng Willem
Publication year - 1986
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430080148
Subject(s) - perfusion , cardiology , medicine , ischemia , blood flow , collateral circulation , infarction , myocardial infarction
The variables related to infarct size were examined in order to develop an efficient procedure for the assessment of cardioprotective action in the dog. In the open chest model the left anterior descending coronary artery was ligated for 90 or 240 min. Regional myocardial blood flow was measured by tracer microspheres and infarct size was studied using triphenyltetrazoliumchloride. Infarct size was measured in relation to perfusion area, collateral flow, and rate pressure product. Using perfusion area as an independent variable, only 61% of the variance in infarct size could be explained. Including collateral flow also, this percentage increased to 80. Using perfusion area and collateral flow, infarct size could be predicted accurately. The usefulness of this procedure is demonstrated by data obtained with test compound R 51 430.