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R 58 735, a novel antihypoxic drug improves memory in rats
Author(s) -
Clincke Gilbert,
Sahgal Arjun
Publication year - 1986
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430080144
Subject(s) - drug , pharmacology , latency (audio) , chemistry , anesthesia , medicine , engineering , electrical engineering
Rats weren given free choice to enter either a black or a white compartment when placed on an illuminated runway. On the fourth day a mild shock was given upon entry. Animals were subsequently injected with either solvent or a dose of R 58 735. Drug treatment dose‐relatedly increased entry latency on retention test (day 5) and doubled choice reversal at the highest dose (25 mg\kg s.c.) given. The results suggest that R 58 735 has a direct, memory enhancing action.