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Ketanserin: A novel cardiovascular drug
Author(s) -
Symoens Jan,
Janssens Monique
Publication year - 1986
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430080119
Subject(s) - ketanserin , medicine , drug , hemodynamics , microcirculation , pharmacology , serotonin , cardiology , 5 ht receptor , receptor
Abstract Extensive clinical investigation has shown that ketanserin is an effective first‐line antihypertensive agent with particular advantages in older patients. It has a favorable hemodynamic profile and seems devoid of serious side‐effects. Clinical studies in various diseases indicate a gradual improvement of the microcirculation, which is compatible with selective serotonin S 2 ‐antagonism. Ketanserin has a favorable influence on several cardiovascular risk factors. Preliminary data suggest that it has vascular protective effects in patients with atherosclerosis.