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Haemodynamic effects in man during exercise of a single oral dose of narbivolol (R 67555), a new beta‐1‐adrenoceptor blocking agent: A comparative study with atenolol, pindolol, and propranolol
Author(s) -
De Crée Jean,
Geukens Hedwig,
Leempoels Jos,
Verhaegen Herman
Publication year - 1986
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430080114
Subject(s) - atenolol , pindolol , propranolol , heart rate , blood pressure , medicine , hemodynamics , endocrinology , beta (programming language) , anesthesia , computer science , programming language
Abstract In eight normal volunteers R 67555 at 5 mg and 10 mg significantly lowered the exercise‐induced increase of systolic blood pressure by 20 and 25%, and the exercise‐induced increase of heart rate by 20 and 21% respectively. The blood pressure lowering effect of R 67555 6 hr after intake was comparable to that observed after atenolol, pindolol, and propranolol. In contrast, the lowering of exercise‐induced increase of heart rate was significantly less with R 67555 than with the other beta‐blockers tested. The ratio of PEP c /LVET c , a measure of left ventricular performance, significantly increased 3 hr after intake aof atenolol, propranolol, and 10 mg of R 67555 but not after pindolol and 5 mg of R 67555. Six hr after administration of pindolol and of 5 mg of R 67555, the ratio PEP C /LVET c was significantly lowered as compared with control values. The post‐exercise left ventricular ejection time (LVET c ) significantly shortened 3 hr and 6 hr after intake of 5 mg and 10 mg of R 67555, whereas a trend to prolongation was observed after administration of atenolol, pindolol, and propranolol.