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Progress on the characterization and identification of endothelium‐derived relaxing factor(s)
Author(s) -
Berkowitz Barry A.,
Ohlstein Eliot H.
Publication year - 1986
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430070402
Subject(s) - arachidonic acid , endothelium derived relaxing factor , chemistry , monooxygenase , endothelium , vasodilation , biochemistry , enzyme , cytochrome p450 , biology , endocrinology , in vitro
Substantial evidence indicates that there are novel factors released from the vascular endothelium that regulate vasodilatation. The weight of the present evidence is that endothelium‐derived relaxing factor(s) (EDRF) is an oxidation product of arachidonic acid. Whether the oxidative enzyme is a lipoxygenase or related to a cytochrome P450 monooxygenase remains under investigation. Future progress requires a reproducible source of EDRF to allow isolation, purification, and structural identification.