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Pentylenetetrazol‐induced antinociceptive responses in the mouse
Author(s) -
Valli M.,
Mesdjian E.,
Tamalet C.,
Jadot G.,
VionDury J.,
DeFeudis F. V.,
Mandel P.
Publication year - 1986
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430070310
Subject(s) - pentylenetetrazol , nociception , convulsant , pharmacology , chemistry , acetic acid , anticonvulsant , medicine , receptor , neuroscience , biology , biochemistry , epilepsy
We describe studies that tested the hypothesis that pentylenetrazol (PTZ) produces analgesia in mice. Indeed, the studies demonstrated analgesia in both of the analgesimetric procedures (hot plate test, acetic acid‐induced writhing response) with a clear degree of separation between the antinociceptive and convulsant doses of PTZ. Antagonists for four neurotransmitters failed to antagonize the analgesia produced by PTZ.