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Prevention of experimental amnesia by peripherally administered cholecystokinin octapeptide in the rat
Author(s) -
Katsuura Goro,
Itoh Shinji
Publication year - 1986
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430070308
Subject(s) - amnesia , cycloheximide , electroconvulsive shock , retrograde amnesia , cholecystokinin , anesthesia , pharmacology , chlorpromazine , medicine , endocrinology , chemistry , receptor , protein biosynthesis , biochemistry , psychiatry
The effect of subcutaneously injected cholecystokinin octapeptide (CCK‐8) on amnesia induced by electroconvulsive shock (ECS), CO 2 inhalation, or cycloheximide injection was investigated in rats. In normal rats, single administration of CCK‐8 had no significant effect on the passive avoidance response. Treatment with ECS, CO 2 , or cycloheximide markedly decreased the latency of the passive avoidance response, but CCK‐8 in doses from 0.1 to 10 μg/kg could prevent the induced amnesia when injected 30 min before the training trials, immediately after foot shock or amnesic treatments, and 30 min before the first retention test. The results indicate that peripheral administration of CCK‐8 is effective in preventing amnesia in the rat.