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Interactions of central acting compounds with hepatic drug‐metabolizing enzyme systems: I. Effects of dsp‐4 on liver microsomal enzymes
Author(s) -
Hock Franz J.,
Beyhl Friedrich E.
Publication year - 1986
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430070209
Subject(s) - microsome , chemistry , enzyme , pharmacology , cytochrome , biochemistry , reductase , drug , glutathione , aniline , medicine , organic chemistry
The action of DSP‐4 [N‐(2‐chloroethyl)‐N‐ethyl‐2‐bromo‐benzylamine] on drug‐metabolizing liver enzymes was studied in the rat. Seventy‐two hours after a single subcutaneous (sc) dose of DSP‐4 (75 mg/kg), mixed‐function oxidases, glucuronyltransferases, and cytochrome P‐450 were decreased, whereas aniline hydroxylase, cytochrome c reductase, and glutathione S ‐transferase remained unchanged. Thus, in addition to DSP‐4′s central action, effects on peripheral organs are also exerted.