Premium
The effects of indomethacin upon physiological indices of gastric mucosal integrity
Author(s) -
Pendleton Robert G.,
Stavorski John M.
Publication year - 1985
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430060408
Subject(s) - pepsin , stomach , potential difference , chemistry , medicine , electrolyte , cats , significant difference , pharmacology , biochemistry , enzyme , electrode
Indomethacin was studied for its effects on three indices of gastric mucosal integrity in anesthetized cats. Following intragastric administration of the compound under conditions of constant stomach acidity and electrolyte concentrations, the transgastric potential difference declined in a gradual, linear fashion during the 210 min of the experimental period. These changes, which were dose related over the range of 1.25‐5 mg/kg of indomethacin, were accompanied by increased concentrations of luminal pepsin and blood. The results suggest that the transgastric potential difference is a sensitive indicator of gastric mucosal integrity under the conditions of this study.