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A preliminary investigation of “albert 285” (HWA 285) on psychomotor performance, mood, and memory
Author(s) -
Hindmarch Ian,
Subhan Zahed
Publication year - 1985
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430050411
Subject(s) - flicker fusion threshold , placebo , psychomotor learning , mood , crossover study , psychology , audiology , memory test , medicine , cognition , psychiatry , alternative medicine , pathology , electrical engineering , flicker , engineering
Eight healthy female volunteers received 150, 300, and 450 mg of HWA 285 and placebo according to a randomized, double‐blind crossover design. The subjects completed a battery of psychological tests including critical flicker fusion (CFF), choice reaction time (CRT), subjective ratings of drug effects (LARS), and a Sternberg memory scanning test (SMST) 1 and 2 hr following treatment. No statistically significant changes from placebo were observed on CFF, CRT, or subjective ratings of drug effects. However, memory as assessed using the Sternberg technique was significantly improved with respect to placebo 1 hr following treatment with HWA 285 at 150, 300, and 450 mg dose levels. The action of the drug was found to be specific in its effects on the central serial comparison stage of the information processing model.