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Modification by diazoxide of canine renal vascular responsiveness to endogenous vasoconstrictors
Author(s) -
Wood William B.,
Sticht Frank D.,
Igbokwe Emmanuel C.,
Cardoso Sergio S.,
Elko Edward E.
Publication year - 1985
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430050309
Subject(s) - diazoxide , vasoconstriction , norepinephrine , medicine , angiotensin ii , endocrinology , renal artery , renal blood flow , blood pressure , renal circulation , kidney , dopamine , insulin
Diazoxide‐induced modification of renal vascular responses to norepinephrine and angiotensin II was studied in dogs. Diazoxide was infused directly into the renal artery in order to minimize the effect of high plasma protein binding and to obtain maximum exposure of the test vessel to the administered drug. During the 30‐min infusion period, renal blood flow showed an initial, transitory increase followed by a progressive decline which paralleled the induced fall in systemic blood pressure. In the presence of diazoxide, renal vasoconstrictor responses to intravenous and intraarterial norepinephrine and intravenous angiotensin II were significantly attenuated. In contrast, the renal vasoconstrictor response to intraarterial angiotensin II was not significantly modified by diazoxide. This differential inhibition by diazoxide of renal vasoconstriction to norepinephrine or angiotensin II may warrant consideration when these pressor agents are being used to overcome the excessive hypotension resulting from inadvertent diazoxide overdosage.