Premium
Effects of some typical and atypical antidepressants on schedule‐controlled responding in rats
Author(s) -
Rastogi S. K.,
McMillan D. E.
Publication year - 1985
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430050307
Subject(s) - maprotiline , mianserin , trazodone , clomipramine , imipramine , nomifensine , pharmacology , component (thermodynamics) , chemistry , psychology , antidepressant , medicine , dopaminergic , alternative medicine , pathology , hippocampus , dopamine , physics , thermodynamics
The effects of tricylic antidepressant drugs with diverse chemical structures were studied in rats on responding maintained under a multiple fixed‐ratio (30) fixed‐interval (5 min) schedule of food resentation. Bupropion, mianserin, and nomifensine increased responding during the first half of the fixed‐interval component and during the fixed‐ratio component of the multiple schedule. Higher doses decreased rates under both the fixed‐ratio component and during the second half of the fixed‐interval component. Trazodone and trimipramine also increased rates of responding during the first half of the fixed‐interval component. Higher doses of these drugs decreased rates under the fixed‐ratio component more than the approximately equal rates during the second half of the fixed‐interval component. Iprindole, protryptyline, fluvoxamine, fluoxetine, maprotiline, clomipramine, imipramine, lithium, and chlorpromazine did not increase rates of responding under the fixed‐ratio component or under either half of the fixed‐interval component. Among these drugs, only imipramine differentially affected the nearly equal rates of responding during the second half of the fixed‐interval component and during the fixed‐ratio component. The effects of antidepressants depended on both the control rate of responding and the schedule. Rate‐increasing effects tended to be associated with antidepressants that interact with dopaminergic systems, but in general, the correlation between behavioral and biochemical effects was low.