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Memory and benzodiazepines: Animal and human studies with 1,4‐benzodiazepines and clobzam (1,5‐benzodiazepine)
Author(s) -
Koeppen D.
Publication year - 1984
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430040509
Subject(s) - benzodiazepine , amnesia , clobazam , anterograde amnesia , lorazepam , retrograde amnesia , temazepam , memory consolidation , anxiolytic , psychology , anxiety , diazepam , sedative , anti anxiety agents , pharmacology , anesthesia , epilepsy , neuroscience , medicine , psychiatry , hippocampus , receptor
The amnesic effects of the 1,4 benzodiazepines make them useful as adjuncts to anesthesia. However, these effects are undesirable in the treatment of anxiety and epilepsy, especially in outpatients. The mode of action of the 1,4‐benzodiazepines on memory is not yet sufficiently identified. These compounds seem to affect the consolidation of information material; anterograde amnesic effects are common, while retrograde amnesia or impairment of short‐term memory have been reported only exceptionally. The 1,5‐benzodiazepine clobazam has shown minimal effects on memory in contrast to the 1,4‐benzodiazepines at therapeutically equipotent doses. These results tally with the less pronounced sedative action of clobazam compared to the 1,4‐benzodiazepines but do not seem to be connected by a causal relationship. The clinical relevance of these findings has to be clarified and the various factors modifying the effects of benzodiazepines on memory (e.g., benzodiazepine dose, type of memory task, individual encoding and decoding strategies, anxiety and neuroticism score) have yet to be characterized.