κ‐Agonist analogesics: Evidence for μ 2  and δ opioid receptor antagonism | Zendy

Wood Paul L. | Zendy

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κ‐Agonist analogesics: Evidence for μ 2 and δ opioid receptor antagonism

Author(s) -

Wood Paul L.

Publication year - 1984

Publication title -

drug development research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.582

H-Index - 60

eISSN - 1098-2299

pISSN - 0272-4391

DOI - 10.1002/ddr.430040406

Subject(s) - antagonism , dadle , pharmacology , agonist , chemistry , antagonist , in vivo , receptor , opioid , opioid receptor , acetylcholine , sch 23390 , biology , biochemistry , microbiology and biotechnology

Despite a unique in vivo pharmacology, K agonists possess moderate to high affinities for μ, δ, and κ binding sites in vitro. By monitoring the antagonist activity of κ agents on morphine‐ and DADLE‐dependent changes in dopamine and acetylcholine metabolism we were able to demonstrate a specific μ 2 and δ receptor antagonism for κ analgesics. Furthermore, this antagonism was probably directly at the receptor level and not physiological.

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