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κ‐Agonist analogesics: Evidence for μ 2 and δ opioid receptor antagonism
Author(s) -
Wood Paul L.
Publication year - 1984
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430040406
Subject(s) - antagonism , dadle , pharmacology , agonist , chemistry , antagonist , in vivo , receptor , opioid , opioid receptor , acetylcholine , sch 23390 , biology , biochemistry , microbiology and biotechnology
Despite a unique in vivo pharmacology, K agonists possess moderate to high affinities for μ, δ, and κ binding sites in vitro. By monitoring the antagonist activity of κ agents on morphine‐ and DADLE‐dependent changes in dopamine and acetylcholine metabolism we were able to demonstrate a specific μ 2 and δ receptor antagonism for κ analgesics. Furthermore, this antagonism was probably directly at the receptor level and not physiological.