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The toxicology of the schistosomicidal agent oxamniquine
Author(s) -
Chvédoff M.,
Faccini J. M.,
Gregory M. H.,
Hull R. M.,
Monro A. M.,
Perraud J.,
Quinton R. M.,
Reinert H. H.
Publication year - 1984
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430040212
Subject(s) - oxamniquine , toxicity , physiology , medicine , necrosis , pharmacology , toxicology , biology , schistosomiasis , immunology , helminths , schistosoma mansoni
Oxamniquine displayed low acute toxicity in mice, hamsters, and rabbits. In rats, however, oxamniquine was much more toxic, the female being 8–10 times more sensitive than the male; single doses elicited an idiosyncratic sex‐linked hepatic necrosis and bile duct proliferation. Dogs given repeated oral doses of 20 or 30 mg/kg/day for 5 successive days every 4 weeks for 11 months showed neurological disturbances of short duration, which tended gradually to increase in severity from one dosage period to the next; no histopathological correlate could be found. In chronic studies in mice (18 months) and hamsters (19 months) with intermittent dosage regimens relevant to likely usage in man, no evidence of carcinogenicity potential was observed at dose levels up to 150 mg/kg. Oxamniquine displayed no maternal toxicity or teratogenicity in mice and rabbits, and only slight embryotoxicity after high oral doses.