The castor oil test in rats: An in vivo method to evaluate antipropulsive and antisecretory activity of antidiarrheals? | Zendy

Niemegeers C. J. E. | Zendy; Awouters F. | Zendy; Janssen P. A. J. | Zendy

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The castor oil test in rats: An in vivo method to evaluate antipropulsive and antisecretory activity of antidiarrheals?

Author(s) -

Niemegeers C. J. E.,

Awouters F.,

Janssen P. A. J.

Publication year - 1984

Publication title -

drug development research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.582

H-Index - 60

eISSN - 1098-2299

pISSN - 0272-4391

DOI - 10.1002/ddr.430040211

Subject(s) - loperamide , diarrhea , excretion , castor oil , in vivo , pharmacology , chemistry , prostaglandin , medicine , endocrinology , biology , biochemistry , microbiology and biotechnology

Castor oil‐induced diarrhea in rats is described to be an appropriate model of the complex, prolonged processes of hypersecretion and accelerated transit that characterize secretory diarrhea. Suprofen, a prostaglandin biosynthesis inhibitor, was found to postpone diarrhea over a wide dose range, but suprofen failed to reduce the diarrheal excretion. In contrast to suprofen, loperamide not only increased the diarrhea‐free period but also produced a dose‐related decrease of the diarrheal excretion.

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