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The castor oil test in rats: An in vivo method to evaluate antipropulsive and antisecretory activity of antidiarrheals?
Author(s) -
Niemegeers C. J. E.,
Awouters F.,
Janssen P. A. J.
Publication year - 1984
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430040211
Subject(s) - loperamide , diarrhea , excretion , castor oil , in vivo , pharmacology , chemistry , prostaglandin , medicine , endocrinology , biology , biochemistry , microbiology and biotechnology
Castor oil‐induced diarrhea in rats is described to be an appropriate model of the complex, prolonged processes of hypersecretion and accelerated transit that characterize secretory diarrhea. Suprofen, a prostaglandin biosynthesis inhibitor, was found to postpone diarrhea over a wide dose range, but suprofen failed to reduce the diarrheal excretion. In contrast to suprofen, loperamide not only increased the diarrhea‐free period but also produced a dose‐related decrease of the diarrheal excretion.