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Effects of alprazolam on the activity of rat cerebellar purkinje neurons: Evidence for mediation by norepinephrine
Author(s) -
Sorensen Stephen,
Freedman Robert
Publication year - 1983
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430030607
Subject(s) - alprazolam , norepinephrine , propranolol , medicine , endocrinology , depressant , catecholamine , neuroscience , chemistry , pharmacology , psychology , dopamine , psychiatry , anxiety
Abstract Acute administration of alprazolam causes a dose‐dependent slowing of the spontaneous discharge of cerebellar Purkinje neurons. This effect is reversed by treatment with propranolol. There is also significantly less slowing in animals in which cerebellar neuronal circuitry has been destroyed by pretreatment with 6‐hydroxydopamine. These data suggest that some of the depressant effects of alprazolam may be mediated by an interaction with norepinephrine.