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Meperidine and normeperidine convulsions in mice: Possible opiate and serotonergic mechanisms
Author(s) -
Bader Steven Roy,
Moore Paul A.
Publication year - 1983
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430030411
Subject(s) - (+) naloxone , serotonergic , opiate , pharmacology , chemistry , anesthesia , medicine , serotonin , opioid , receptor
The effects of naloxone and 5‐hydroxytryptophan (5‐HTP) pretreatment on convulsions induced by meperidine and normeperidine were studied in male Swiss‐Webster mice. The CD50 (95% confidence limits) was found to be 17.5 mg/kg (15.6–19.6) for meperidine and 38.0 mg/kg (36.2–39.9) for normeperidine administered intravenously. Convulsions induced by meperidine (17.5 mg/kg) were significantly attenuated by naloxone (30 mg/kg) pretreatment but not by 5‐HTP pretreatment alone. Normeperidine (38.0 mg/kg) induced convulsions were significantly attenuated by 5‐HTP pretreatment, but not by naxolone pretreatment. The administration of a combined dose of meperidine and normeperidine does not produce a supra‐additive response.